2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140665
    Azide-PEG-azide (MW 5000)
    Azide-PEG-azide (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-azide (MW 5000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-azide (MW 5000)
  • HY-W096134
    Benzyloxy-C5-PEG1 159028-70-3
    Benzyloxy-C5-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyloxy-C5-PEG1
  • HY-133311
    Hydroxy-PEG8-CH2-Boc 2869101-36-8
    Hydroxy-PEG8-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG8-CH2-Boc
  • HY-138416
    Azido-PEG10-CH2COOH
    Azido-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-CH2COOH
  • HY-134688
    Iodoacetamide-PEG5-NH2
    Iodoacetamide-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Iodoacetamide-PEG5-NH2
  • HY-138728
    Mal-amido-PEG5-acid
    Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG5-acid
  • HY-157737
    GVSKYG-PEG2-azide TFA
    GVSKYG-PEG2-azide (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    GVSKYG-PEG2-azide TFA
  • HY-140320
    DBCO-mPEG (MW 10kDa)
    DBCO-mPEG (MW 10kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 10kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-mPEG (MW 10kDa)
  • HY-138464
    Br-Boc-C2-azido 1120364-53-5
    Br-Boc-C2-azido is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Br-Boc-C2-azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Br-Boc-C2-azido
  • HY-140357
    Tos-PEG9 62573-11-9
    Tos-PEG9 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG9
  • HY-138404
    THP-PEG2-Mal
    THP-PEG2-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG2-Mal
  • HY-138400
    Me-PEG18-NH2
    Me-PEG18-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Me-PEG18-NH2
  • HY-133370
    DBCO-NHCO-PEG7-acid
    DBCO-NHCO-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG7-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG7-acid
  • HY-141065
    N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 2107273-70-9
    N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5
  • HY-138516
    CG-PEG5-azido
    CG-PEG5-azido is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. CG-PEG5-azido is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    CG-PEG5-azido
  • HY-130742
    Azido-PEG8-Boc 1623791-99-0
    Azido-PEG8-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-Boc
  • HY-140269
    DBCO-PEG12-acid 2754384-72-8
    DBCO-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-acid
  • HY-130885
    N3-PEG6-Propanehydrazide
    N3-PEG6-Propanehydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG6-Propanehydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG6-Propanehydrazide
  • HY-140201
    Amino-PEG6-amido-C16-Boc
    Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG6-amido-C16-Boc
  • HY-138315
    Ms-PEG6-THP 42607-89-6
    Ms-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG6-THP
PROTAC Linkers Isoform Comparison

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